Cordless-Microscope
All about Cordless-Microscope.A Totally New Matrix Gemini LIMS For The 21ST Century
A Totally New Matrix Gemini LIMS For The 21ST Century
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Other Articles:
| • | Cell Patterning: Interaction of Cardiac Myocytes and Fibroblasts in Three-Dimensional Culture |
| Research Articles Troy A. Baudino, Alex McFadden, Charity Fix, Joshua Hastings, Robert Price, Thomas K. Borg, Microscopy and Microanalysis, Volume 14 Issue 02 , pp 117-125 Abstract Patterning of cells is critical to the formation and function of the normal organ, and it appears to be dependent upon internal and external signals. Additionally, the formation of most tissues requires the interaction of several cell types. Indeed, both extracellular matrix (ECM) components and cellular components are necessary for three-dimensional (3-D) tissue formation in vitro. Using 3-D cultures we demonstrate that ECM arranged in an aligned fashion is necessary for the rod-shaped phenotype of the myocyte, and once this pattern is established, the myocytes were responsible for the alignment of any subsequent cell layers. This is analogous to the in vivo pattern that is observed, where there appears to be minimal ECM signaling, rather formation of multicellular patterns is dependent upon cell cell interactions. Our 3-D culture of myocytes and fibroblasts is significant in that it models in vivo organization of cardiac tissue and can be used to investigate interactions between fibroblasts and myocytes. Furthermore, we used rotational cultures to examine cellular interactions. Using these systems, we demonstrate that specific connexins and cadherins are critical for cell cell interactions. The data presented here document the feasibility of using these systems to investigate cellular interactions during normal growth and injury. |
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| • | Complementary and Alternative Medicine in Present Day Oncology Care: Promises and Pitfalls |
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Cancer is already a well-recognized global phenomenon. The traditional approaches to cancer therapy have been surgery, radiotherapy and chemotherapy. These modalities have shown considerable promise and presently form cornerstones of management of most malignancies. However, these conventional approaches have associated toxicities and suffer from limitations in curing advanced lesions. Complementary and alternative medicine (CAM), for reasons varying from cost to accessibility, has assumed significant importance in cancer therapy. In this article, we review the prominent modalities in CAM in present day cancer management and critically analyze their emerging potential into an evidence-based oncology practice. |
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| • | Congratulations to Dr David Fleming |
| Our congratulations to Dr David Fleming who recently completed his viva examination for PhD. The examiners were Dr David Sliney and Dr Pat Goodman. Dr Fleming was supervised by Dr James Walsh. See David Fleming's Postgrad Page. |
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| • | Youth Involved in Major Scientific Announcement |
Today, National Geographic announced a major archaeological find in the Sahara. Follow the link to read more about the science. However, what is most relevant to readers of this blog is the involvement of Chicago-area teens in the announcement. The African gravesite was found by an expedition led by paleontologist Paul Sereno, who is also co-founder of Project Exploration, a non-profit science education organization that connects science to the public - especially minority youth. Some of those youth traveled to Niger as part of the excavation team, and still more were involved in the production of today's public announcement. Read here about Shureice, one of the junior paleontologists involved in the program. Many scientists will tell you that communicating their findings to the public is one of the hardest parts of their job. Project Exploration gives youth an early opportunity to experience the science and the communication. Visit their website announcing the find, and you should be impressed by how well they do it. |
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| • | Comparison of Zones 1 to 4 Flexor Tendon Repairs Using Absorbable and Unabsorbable Four-strand Core Sutures |
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Absorbable sutures behave favourably in vitro and in an animal model. We report the outcome of flexor tendon injuries in a series of 272 consecutive patients treated over 45 months with a mean follow-up of 4 (range 3–12) months. Five hundred and seventy-six tendons were repaired in 416 digits. The patients were not randomised and all repairs were performed using a Strickland four-strand core technique. In 191 (73%) patients an absorbable core suture was used (Group 1) and in 81 (27%) a non-absorbable material was used (Group 2). There were six ruptures (2%) in Group 1 and two (2%) in Group 2. Using the original Strickland criteria, there were 72% excellent/good and 28% fair/poor results in the absorbable core suture group, and 73% and 27%, respectively, in the non-absorbable core suture group. This study suggests that appropriate absorbable core sutures can be used safely for flexor tendon repair. |
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| • | Development of a stage-scanning system for high-resolution confocal STEM |
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A stage-scanning system is composed of a specially designed transmission electron microscopy specimen holder equipped with a piezo-driven specimen stage, power supplier and control software. This system enables the specimen to be scanned three-dimensionally, and therefore confocal scanning transmission electron microscopy (STEM) can be performed with a fixed electron-optics configuration. It is demonstrated that stage-scanning confocal STEM images can be obtained with the lateral atomic resolution and the specimen can be moved three-dimensionally with high precision. |
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