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Tony Wright Asks If Brain Development Has Been Halted By By Eating Habits




A British plant biologist believes he has discovered why our brains stopped developing thousands of years ago and why we all have the potential to become geniuses.


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Quantitative Energy Dispersive X-ray Microanalysis of Electron Beam-Sensitive Alloyed Nanoparticles
Research Articles
Nadi Braidy, Zygmunt J. Jakubek, Benoit Simard, Gianluigi A. Botton,
Microscopy and Microanalysis, Volume 14 Issue 02 , pp 166-175

Abstract
An energy dispersive X-ray spectrometry (EDXS) method is developed to evaluate the composition of alloyed nanoparticles (NPs) where one of the alloying elements is removed under the electron beam during microanalysis with a transmission electron microscope (TEM). The method is demonstrated for alloyed Au-Ag NPs of a diameter ranging from 6 to 20 nm produced by laser evaporation of a water-suspended Ag-Au powder mixture of varying composition. Series of EDXS spectra are recorded for 30 NPs from samples with five different Ag:Au ratios revealing Ag depletion from NPs during electron irradiation. By studying the evolution of NPs composition as a function of dose, the initial Ag content for each NP is extrapolated. The rate of Ag depletion is discussed in terms of sputtering and knock-on damage. On average, approximately one Ag atom is lost from the NP for each Ag L X-ray detected. To assess the limitations of microanalysis in these sensitive nanoscale structures, the concept of detectability limit is adapted to our method. This benchmark is then evaluated for Ag in Au-Ag NPs of various sizes and acquisition times. This study should be regarded as a guide for the design of analytical TEM measurements of beam-sensitive NPs.
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Follicular Lymphoma of the Duodenum: A Clinicopathologic Analysis of 26 Cases
Objective

Follicular lymphomas (FLs) occur commonly in the lymph nodes, and duodenal FL (DFL) is reported to be rare.

Methods

We analysed the clinical, morphological, immunohistochemical and genetic features of 26 cases of DFL. Primary DFLs and systemic FLs that involved the duodenum at any point during the clinical course were included in the analysis.

Results

Typically, primary DFLs (14 cases) were found incidentally at routine medical check-ups, whereas involvement of the duodenum by systemic FLs (12 cases) was found through staging procedures. All cases involved the second portion of the duodenum. Helicobacter pylori infection was common (71%). In all cases, the histologic grade was low (either grade 1 or 2), and CD20, CD10 and Bcl-2 were positive by immunohistochemistry. Immunoglobulin heavy chain gene (IGH) and bcl-2 gene (BCL2) fusion was frequently shown by fluorescence in situ hybridization (FISH) analysis: nine of 12 cases (75%) of primary DFL and 10 of 12 cases (83%) of systemic DFL were positive. Treatment regimens employed were rituximab (R) plus chemotherapy (10), R (6), chemotherapy (3), irradiation (3) and the other three patients were subjected to observation. After a median follow-up duration of 40 months (ranging 11–96 months), 17 patients were alive without disease, seven were alive with disease and one had died of lymphoma.

Conclusions

Primary DFLs resemble systemic and nodal FLs, except that the former has high incidence of early stage and low-grade histology. The duodenum appears to be a frequently involved extranodal site of FL with IGH/BCL2.

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New Quantum State of Matter?
In a Nature article published yesterday, Princeton University scientists have shown that the Quantum Hall Effect can occur in nature in a way that wasn't predicted - they've recorded the behavior of electrons in a bulk crystal of bismuth-antimony without any external magnetic field being present. The fundamental research could also lead to advances in new kinds of fast quantum or "spintronic" computing devices.

The Quantum Hall Effect has only been seen previously in atomically thin layers of semiconductors in the presence of a very high applied magnetic field.

See Science Daily.
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Summer Invention Camp
Here is some good press for "Camp Invention." These are week-long camps using materials provided by the National Inventors Hall of Fame. According to the article, they are reaching about 60,000 kids in 47 states.

Camp Invention has a sister program, Club Invention, that is designed for use in after-school programs during the regular school year. Here is a review of that program in the Consumer's Guide to Afterschool Science Resources.
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Early Return to Work Following Open Carpal Tunnel Decompression in Lamb Freezing Workers

Carpal tunnel syndrome is common at the largest lamb processing plant in the world, especially in new lamb boners. The purpose of this study was to establish the incidence and whether expeditious return to work following open carpal tunnel decompression was possible. Two hundred patients with a neurophysiologically confirmed diagnosis underwent surgery between 2002 and 2006. One hundred and eighty-seven patients were assessed retrospectively and 13 prospectively. The incidence in new lamb boners was 10% in their first season. On average, workers commenced rehabilitation at 11 days post-operatively and full duties at 29 days post-operatively with minimal further time off taken. Ninety percent returned to their previous role. By 8 weeks in the prospective group visual analogue pain scores had improved from 8.75 to 2.0 (P<0.01) and Quick Disabilities of the Arm, Shoulder and Hand (QuickDASH) scores had improved from 140 points to 68 (P<0.01). Grip/pinch testing, static two-point discrimination scores and complication rates were comparable with previous studies. This study provides good evidence that coordinated, early rehabilitation and return to work is effective in a high-demand population.

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Preparation of TEM samples of ferritic alloys

We describe techniques for electropolishing irradiated ferritic specimens for examination under the TEM in situations where the foil quality is of utmost importance. First, we describe some modifications to the standard technique for making plan-view specimens aimed at optimizing the foil quality. Second, we describe a technique for making plan-view specimens from a region of buried damage in a specimen irradiated with 2 MeV Fe+ ions.

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