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2008 Nobel Prize in Physics breaks symmetry




The 2008 Nobel Prize in Physics relates to broken symmetry discoveries which led to the quark model.

The Royal Swedish Academy of Sciences has decided to award the Nobel Prize in Physics for 2008 with half to Yoichiro Nambu of the Enrico Fermi Institute, University of Chicago, IL, USA "for the discovery of the mechanism of spontaneous broken symmetry in subatomic physics" and the other half jointly to Makoto Kobayashi, High Energy Accelerator Research Organization (KEK), Tsukuba, Japan and Toshihide Maskawa,Yukawa Institute for Theoretical Physics (YITP), Kyoto University, Japan "for the discovery of the origin of the broken symmetry which predicts the existence of at least three families of quarks in nature".

See Nobel Prize Announcement.


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Nonlinear Optical Imaging of Cellular Processes in Breast Cancer
Research Articles
Paolo P. Provenzano, Kevin W. Eliceiri, Long Yan, Aude Ada-Nguema, Matthew W. Conklin, David R. Inman, Patricia J. Keely,
Microscopy and Microanalysis, Volume 14 Issue 06 , pp 532-548

Abstract
Nonlinear optical imaging techniques such as multiphoton and second harmonic generation (SHG) microscopy used in conjunction with novel signal analysis techniques such as spectroscopic and fluorescence excited state lifetime detection have begun to be used widely for biological studies. This is largely due to their promise to noninvasively monitor the intracellular processes of a cell together with the cell's interaction with its microenvironment. Compared to other optical methods these modalities provide superior depth penetration and viability and have the additional advantage in that they are compatible technologies that can be applied simultaneously. Therefore, application of these nonlinear optical approaches to the study of breast cancer holds particular promise as these techniques can be used to image exogeneous fluorophores such as green fluorescent protein as well as intrinsic signals such as SHG from collagen and endogenous fluorescence from nicotinamide adenine dinucleotide or flavin adenine dinucleotide. In this article the application of multiphoton excitation, SHG, and fluorescence lifetime imaging microscopy to relevant issues regarding the tumor-stromal interaction, cellular metabolism, and cell signaling in breast cancer is described. Furthermore, the ability to record and monitor the intrinsic fluorescence and SHG signals provides a unique tool for researchers to understand key events in cancer progression in its natural context.
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Potential Utility of Peripherally Applied Loperamide in Oral Chronic Graft-versus-host Disease Related Pain

Four patients with oral chronic graft-versus-host disease pain were treated with loperamide oral-rinse solution. Two-week continued use of the drug solution improved not only the pain scores but also the pain-causing disabilities associated with eating, drinking and sleeping, with no noticeable side effects. Current results suggest that the mu-opioid agonist, loperamide, has a potential analgesic effect that could be clinically used as a peripheral analgesic agent for stomatits pain. However, these observations will need to be further confirmed in a randomized-controlled trial.

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Comment on 'Electron holography on dynamic motion of secondary electrons around sciatic nerve tissues'

We present an alternative interpretation of the holographic phase dislocation loops revealed by Shindo et al. [J. Electron Microsc. 56(1): 1–5 (2007)] around a charged sample. Our interpretation does not involve the motion of secondary electrons around a charged object. It relates, instead, to fluctuating charges on the sample and to the resulting Moiré-type patterns in the hologram.

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