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All about Cordless-Microscope.Chemoradiotherapy for Locally Recurrent Nasopharyngeal Carcinoma: Treatment Outcome and Prognostic Factors
Chemoradiotherapy for Locally Recurrent Nasopharyngeal Carcinoma: Treatment Outcome and Prognostic Factors
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To evaluate the treatment outcome of patients with locally recurrent nasopharyngeal carcinoma (NPC) treated with re-irradiation and chemotherapy.
Between 1991 and 2004, 36 patients with locally recurrent NPC received re-irradiation and chemotherapy. The median re-irradiation dose was 37.9 Gy; the median total dose of prior irradiation and re-irradiation was 104.4 Gy. The outcome is studied retrospectively and also evaluated the prognostic factors and toxicities.
With a median follow-up of 40 months, 3-year overall survival (OS) was 58.3% and 3-year progression-free survival (PFS) was 25.0%. Patients aged <50 and of early stage at recurrence had a significantly better OS and PFS. Over Grade 3 of late toxicities were seen in patients received a total dose of >110 Gy.
Age and stage at recurrence were identified as prognostic factors for OS and PFS. Patients received external beam radiation therapy at a total dose of more than 110 Gy should be careful for severe late toxicities, and it is thought to be the optimal dose for recurrent tumor.
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Other Articles:
| • | Cardiovascular Imaging Using Two-Photon Microscopy |
| Research Articles John A. Scherschel, Michael Rubart, Microscopy and Microanalysis, Volume 14 Issue 06 , pp 492-506 Abstract Two-photon excitation microscopy has become the standard technique for high resolution deep tissue and intravital imaging. It provides intrinsic three-dimensional resolution in combination with increased penetration depth compared to single-photon confocal microscopy. This article will describe the basic physical principles of two-photon excitation and will review its multiple applications to cardiovascular imaging, including second harmonic generation and fluorescence laser scanning microscopy. In particular, the capability and limitations of multiphoton microscopy to assess functional heterogeneity on a cellular scale deep within intact, Langendorff-perfused hearts are demonstrated. It will also discuss the use of two-photon excitation-induced release of caged compounds for the study of intracellular calcium signaling and intercellular dye transfer. |
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| • | Independent Lab Results Prove Like New Gold Is Effective For Killing Highly Concentrated E.Coli |
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| • | "Fossil imprint" of Tycho Brahe's 1572 supernova reported in Nature. |
| 'In 1572, a "new star" appeared in the sky which stunned astronomers and exploded ancient theories of the universe. Now the supernova recorded by Tycho Brahe has been glimpsed again, by Max Planck Institute scientists. They used telescopes in Hawaii and Spain to capture faint light echoes of the original explosion, reflected by interstellar dust. This "fossil imprint" of Tycho's famous supernova is reported in Nature. The study will help solve a 400-year-old mystery over the nature of the celestial event which captivated observers across the globe.' The link below has a movie as well as further details. See BBC News. |
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| • | Temporary Ectopic Digital Implantation: A Clinical Series of Eight Digits |
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This paper reports our experience with temporary ectopic digital implantation. Four patients suffered 12 digital amputations with large defect over the proximal stumps. Only 8 digits were suitable for microsurgical salvage but the local conditions made direct replantation impossible. In our first patient, the two digits were ectopically implanted onto the foot, while in the second patient the four amputated digits were implanted onto the opposite forearm. After stump reconstruction, the digits were microsurgically transferred to the hand, restoring a functional pinch. One digit suffered a venous congestion and necrosis in the ectopic site caused by a haematoma and another experienced a no-reflow phenomenon. In conclusion, temporary ectopic implantation remains a procedure that can be used to salvage amputated digits. |
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| • | Rapid autotuning for crystalline specimens from an inline hologram |
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A method to measure the aberration function for a crystalline specimen from a single inline hologram or ‘Ronchigram’ by dividing it up into small patches is derived. Measurement of aberrations is demonstrated from both dynamical simulations and experimental Ronchigrams. This method should allow rapid fine-tuning on a variety of crystalline specimens and represents a key step toward active optics for scanning transmission electron microscopy. |
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