Cordless-Microscope
All about Cordless-Microscope.Irinotecan Plus Cisplatin Therapy and S-1 Plus Cisplatin Therapy for Advanced or Recurrent Gastric Cancer in a Single Institution
Irinotecan Plus Cisplatin Therapy and S-1 Plus Cisplatin Therapy for Advanced or Recurrent Gastric Cancer in a Single Institution
 |
 |
 |
From the results of the JCOG9912 and SPIRITS trials, S-1 plus cisplatin (CDDP) therapy (SP) has been recognized as the standard chemotherapy for advanced gastric cancer in Japan. However, in their subsets of patients with the target lesion, irinotecan (CPT-11) plus CDDP therapy (IP) resulted in longer survival than 5-fluorouracil alone while SP exhibited a survival similar to S-1 alone. The objective of this study was to clarify the safety and efficacy of these two regimens.
Forty-four patients were treated with IP and 32 with SP between September 2002 and July 2006 at Shizuoka Cancer Center. In IP, 70 mg/m2 CPT-11 was administered on Days 1 and 15, 80 mg/m2 CDDP on Day 1, repeated every 4 weeks. In SP, 40–60 mg S-1 depending on the patient’s body surface area was given orally twice daily for 21 days and 60 mg/m2 CDDP intravenously on Day 8, repeated every 5 weeks.
The response rate, progression-free survival and median survival were 47% (17 of 36), 170 and 444 days in IP, and 80% (21 of 26), 235 and 469 days in SP. In patients with target lesions, those were 47%, 170 and 431 days in IP, and 80%, 235 and 442 days in SP. The incidence of Grade 3 or 4 toxicity was similar in both groups, but patient refusal of treatment was more frequent for IP than for SP.
Our results demonstrate a better efficacy and feasibility of SP than IP for advanced gastric cancer patients, with or without a target lesion.
Click Here to read the entire article...
Other Articles:
| • | In-Depth Fluorescence Lifetime Imaging Analysis Revealing SNAP25A-Rabphilin 3A Interactions |
| Research Articles Jiung-De Lee, Ping-Chun Huang, Yi-Cheng Lin, Lung-Sen Kao, Chien-Chang Huang, Fu-Jen Kao, Chung-Chih Lin, De-Ming Yang, Microscopy and Microanalysis, Volume 14 Issue 06 , pp 507-518 Abstract The high sensitivity and spatial resolution enabled by two-photon excitation fluorescence lifetime imaging microscopy/fluorescence resonance energy transfer (2PE-FLIM/FRET) provide an effective approach that reveals protein-protein interactions in a single cell during stimulated exocytosis. Enhanced green fluorescence protein (EGFP) labeled Rabphillin 3A (RPH3A) were co-expressed in PC12 cells as the FRET donor and acceptor, respectively. The FLIM images of EGFP-SNAP25A suggested that SNAP25A/RPH3A interaction was increased during exocytosis. In addition, the multidimensional (three-dimensional with time) nature of the 2PE-FLIM image datasets can also resolve the protein interactions in the z direction, and we have compared several image analysis methods to extract more accurate and detailed information from the FLIM images. Fluorescence lifetime was fitted by using one and two component analysis. The lifetime FRET efficiency was calculated by the peak lifetime ( 1/2), respectively. The results show that FRET efficiency increased at cell surface, which suggests that SNAP25A/RPH3A interactions take place at cell surface during stimulated exocytosis. In summary, we have demonstrated that the 2PE-FLIM/FRET technique is a powerful tool to reveal dynamic SNAP25A/RPH3A interactions in single neuroendocrine cells. |
|
| Click Here to read the entire article... |
|
| • | New Book Offers Scientific Look At Love |
 Click Here to read the entire article... |
|
| • | The Large Hadron Collider: Shedding Light on the Dark Universe |
| If you missed it, you can now watch online "The Large Hadron Collider: Shedding Light on the Dark Universe", the talk by Prof. Rolf-Dieter Heuer. Recorded November 24th at the RDS by HEAnet. The world may soon have a deeper understanding than ever before about the origins and workings of the Universe thanks to the remarkable Large Hadron Collider (LHC). Built in a tunnel one kilometre beneath Switzerland’s Jura mountains, this €4 billion physics experiment will smash atoms together at colossal speeds to create energies not seen since just after the Big Bang. See streamed lecture. |
|
| Click Here to read the entire article... |
|
| • | |
| Click Here to read the entire article... |
|
| • | Outcome of Conservative Management of Spiral/Long Oblique Fractures of the Metacarpal Shaft of the Fingers Using a Palmar Wrist Splint and Immediate Mobilisation of the Fingers |
|
Conservative management of spiral/long oblique fractures of the shaft of the metacarpal almost always results in shortening and hence these fractures have the reputation of ending up with an extension lag and reduced grip strength. In a prospective study, 42 patients with 54 fractures were treated with a palmar wrist splint and immediate mobilisation of all finger joints. All fractures united. Extension lag of fractured fingers was initially seen in all fingers, but eventually recovered. Grip strength progressively increased to reach a mean of 94% of the contralateral hand by 1 year after injury. |
|
| Click Here to read the entire article... |
|
| • | A new device for high-pressure freezing of cultured cell monolayer using 10-{micro}m-thin stainless discs as both culture plate and specimen carrier |
|
High-pressure freezing (HPF) has been generally accepted as the most reliable method for cryofixation of biological samples, yielding a deep vitreous freezing. In recent cell biology, mammalian cultured cells are widely used, but HPF of cultured cell monolayer has not reached its full potential. In this study, we developed a new reliable device for HPF of cultured cell monolayer by using a 10-µm-thin stainless disc both as culture plate and specimen carrier. We describe the practical procedure, and demonstrate fine structures of HeLa cells cultured and cryofixed on the stainless discs as results. |
|
| Click Here to read the entire article... |
|
By ADMIN_MAIL - version: v1.5 build A