Cordless-Microscope
All about Cordless-Microscope.The Large Hadron Collider: Shedding Light on the Dark Universe
The Large Hadron Collider: Shedding Light on the Dark Universe
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The world may soon have a deeper understanding than ever before about the origins and workings of the Universe thanks to the remarkable Large Hadron Collider (LHC). Built in a tunnel one kilometre beneath Switzerland’s Jura mountains, this €4 billion physics experiment will smash atoms together at colossal speeds to create energies not seen since just after the Big Bang.
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Other Articles:
| • | Nonlinear Optical Imaging of Cellular Processes in Breast Cancer |
| Research Articles Paolo P. Provenzano, Kevin W. Eliceiri, Long Yan, Aude Ada-Nguema, Matthew W. Conklin, David R. Inman, Patricia J. Keely, Microscopy and Microanalysis, Volume 14 Issue 06 , pp 532-548 Abstract Nonlinear optical imaging techniques such as multiphoton and second harmonic generation (SHG) microscopy used in conjunction with novel signal analysis techniques such as spectroscopic and fluorescence excited state lifetime detection have begun to be used widely for biological studies. This is largely due to their promise to noninvasively monitor the intracellular processes of a cell together with the cell's interaction with its microenvironment. Compared to other optical methods these modalities provide superior depth penetration and viability and have the additional advantage in that they are compatible technologies that can be applied simultaneously. Therefore, application of these nonlinear optical approaches to the study of breast cancer holds particular promise as these techniques can be used to image exogeneous fluorophores such as green fluorescent protein as well as intrinsic signals such as SHG from collagen and endogenous fluorescence from nicotinamide adenine dinucleotide or flavin adenine dinucleotide. In this article the application of multiphoton excitation, SHG, and fluorescence lifetime imaging microscopy to relevant issues regarding the tumor-stromal interaction, cellular metabolism, and cell signaling in breast cancer is described. Furthermore, the ability to record and monitor the intrinsic fluorescence and SHG signals provides a unique tool for researchers to understand key events in cancer progression in its natural context. |
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| • | Oral Fluoropyrimidines (Capecitabine or S-1) and Cisplatin as First Line Treatment in Elderly Patients with Advanced Gastric Cancer: A Retrospective Study |
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This study aimed to evaluate the safety and efficacy of oral fluoropyrimidines and cisplatin therapy in elderly patients with untreated advanced gastric cancer (AGC) retrospectively. In addition, we evaluated the relative activity and toxicity of these agents in this patient population. Clinical data from 72 patients with previously untreated AGC, who were treated with capecitabine/cisplatin and S-1/cisplatin, were reviewed. Oral fluoropyrimidines were administered orally twice a day on Days 1–14. The dose of capecitabine was 1250 mg/m2 and that of S-1 was 50 mg [body surface area (BSA) < 1.5 m3] or 60 mg (BSA > 1.5 m3) twice a day. Cisplatin was administered intravenously on Day 1 (before the first dose of capecitabine or S-1) at a dose of 70 mg/m2 over a 2 h period. The chemotherapy cycle was of 3 weeks (with oral capecitabine or S-1). Thirty-two and 40 patients received the S-1 and capecitabine regimens, respectively, and were included in the analysis. The S-1 protocol had a response rate of 40.6%, a median time-to-progression (TTP) of 5.4 months and a median survival of 9.6 months. The capecitabine had a response rate of 55%, a median TTP of 5.9 months and a median survival of 10.2 months. Each protocol had a similar incidence of Grade 3 or 4 adverse events. However, there was a higher rate of the hand–foot syndrome (6 versus 37%) and diarrhea (25 versus 32%) in the capecitabine group. Oral fluoropyrimidines and cisplatin in elderly patients with untreated AGC showed encouraging results. The treatment was well tolerated with a manageable toxicity profile. The comparison of S-1 with capecitabine showed that capecitabine had a slightly higher response rate (statistically not significant) in addition to a higher rate of adverse events such as the hand–foot syndrome and diarrhea. These data should be warranted with further prospective studies. |
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| • | Navy Engineering Camp |
With summer programs in full swing, the articles about summer science learning are starting as well. Here is one about a Navy-sponsored program, the Patriots Technology Training Center, in Maryland. This quote is specifically about recruiting Navy engineers, but it could probably apply to any program looking to engage kids in math and science: "We need to get the word-of-mouth to spread things. What we are finding is that kids are generating their own interest and it spreads very positively." The idea that science and engineering are "not cool" is mostly an adult construction that kids pick up on. Building submarines can be cool, as long as adults don't make kids sit in a classroom and get lectured about submarines. |
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| • | Plate Fixation in Closed Ipsilateral Multiple Metacarpal Fractures |
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Closed multiple metacarpal fractures are uncommon. They are usually associated with significant soft tissue swelling. Early stable fixation and functional rehabilitation optimises outcome. We present a review of 19 patients with 43 metacarpal fractures treated by early open reduction and internal fixation with 2 mm plates. Eighteen patients recovered a full range of motion, while one patient was lost to follow-up. Implant removal on account of extensor irritation was required in only two metacarpals in two patients. Plating of multiple closed metacarpal fractures is a safe, reliable and consistently reproducible treatment method. |
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| • | Comment on 'Electron holography on dynamic motion of secondary electrons around sciatic nerve tissues' |
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We present an alternative interpretation of the holographic phase dislocation loops revealed by Shindo et al. [J. Electron Microsc. 56(1): 1–5 (2007)] around a charged sample. Our interpretation does not involve the motion of secondary electrons around a charged object. It relates, instead, to fluctuating charges on the sample and to the resulting Moiré-type patterns in the hologram. |
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